Sarcopenia – Age-Related Muscle Wasting and Weakness: Mechanisms and Treatments

Εξώφυλλο
Gordon S. Lynch
Springer Science & Business Media, 30 Νοε 2010 - 479 σελίδες
0 Κριτικές
Some of the most serious consequences of aging are its effects on skeletal muscle. ‘Sarcopenia’, the progressive age-related loss of muscle mass and associated muscle weakness, renders frail elders susceptible to serious injury from sudden falls and fractures and at risk for losing their functional independence. Not surprisingly, sarcopenia is a significant public health problem throughout the developed world. There is an urgent need to better understand the neuromuscular mechanisms underlying age-related muscle wasting and to develop therapeutic strategies that can attenuate, prevent, or ultimately reverse sarcopenia. Significant research and development in academic and research institutions and in pharmaceutical companies is being directed to sarcopenia and to related health issues in order to develop and evaluate novel therapeutics. This book provides the latest information on sarcopenia from leading international researchers studying the cellular and molecular mechanisms underlying age-related changes in skeletal muscle and identifies strategies to combat sarcopenia and related muscle wasting conditions and neuromuscular disorders. The book provides a vital resource for researchers and practitioners alike, with information relevant to gerontologists, geriatricians, sports medicine physicians, physiologists, neuroscientists, cell biologists, endocrinologists, physical therapists, allied health and musculoskeletal practitioners, strength and conditioning specialists, athletic trainers, and students of the medical and biomedical sciences.
 

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Περιεχόμενα

Overview of Sarcopenia
1
Cachexia Versus Sarcopenia
9
AgeRelated Remodeling of Neuromuscular Junctions
37
AgingRelated Changes Motor Unit Structure and Function
55
AgeRelated Decline in Actomyosin Structure and Function
75
ExcitationContraction Coupling Regulation in Aging Skeletal Muscle
113
Alterations in Mitochondria and Their Impact in Aging Skeletal Muscle
135
Age Injury and Disease
159
Proteomic and Biochemical Profiling of Aged Skeletal Muscle
259
Exercise and Nutritional Interventions to Combat AgeRelated Muscle Loss
289
Reactive Oxygen Species Generation and Skeletal Muscle Wasting Implications for Sarcopenia
317
Exercise as a Countermeasure for Sarcopenia
333
Role of ContractionInduced Injury in AgeRelated Muscle Wasting and Weakness
373
Role of IGF1 in AgeRelated Loss of Skeletal Muscle Mass and Function
393
Implications for Sarcopenia
419
Implications for Sarcopenia
449

Nuclear Apoptosis and Sarcopenia
173
AgeRelated Changes in the Molecular Regulation of Skeletal Muscle Mass
207
Implications for Sarcopenia
223

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