Alcoholism: A Molecular PerspectiveT. Norman Palmer Springer Science & Business Media, 06.12.2012 - 376 Seiten This book contains selected proceedings from the NATO Advanced Study Institute (AS I) "The Molecular Pathology of Alcoholism" held at the Hotel Il Ciocco in Tuscany during 26th August - 6th September 1990. Alcoholism remains one of the most challenging problems in medical care, with far-reaching medical, social and economic consequences. For example in the U. S. , estimates indicate that 18 million people have a serious drinking problem and that the total cost to the economy of alcohol abuse is $117 billion. Treatment of alcohol dependence and other alcohol-related disorders accounts for almost 15% of the total health bill of the United States. Despite the scale of the medical problem, biomedical research on alcoholism remains something of a 'Cinderella science'. Research funding from government and other bodies is relatively poor and the number of medical scientists working in the field remains small. The Organizing Committee for this NATO ASI, comprising Charles Lieber (New York), Timothy Peters (London), Mario Dianzani (Torino), Emanuele Albano (Torino) and Norman Palmer (perth, Director), were therefore particularly grateful to the NATO Scientific Affairs Division for their active support of this AS I, the first dealing with a topic related to alcohol abuse. We moreover hope that this support will continue. The theme of the ASI was an in depth discussion of the molecular events initiated by alcohol abuse that culminate in onset of alcohol-related disease. |
Inhalt
1 | |
Regulation of rates of ethanol metabolism and liver | 27 |
Acetaldehyde adducts and excessive alcohol consumption | 71 |
Ethanolinduced phosphorylation of cytokeratins in primary | 89 |
Comparison with | 107 |
Changes in the inducibility of a hepatic aldehyde dehydrogenase | 115 |
Biochemical and genetic studies in ALDH₁deficient subjects | 139 |
Simple solutions for complex traits? | 161 |
An in vivo study 211 | 210 |
Chronic alcoholism malnutrition and folate deficiency | 237 |
Alcohol and protein turnover 253 | 252 |
Role of thiamine deficiency in the pathogenesis of alcoholic peripheral | 269 |
Metabolism of ethanol and higher alcohols present in alcoholic drinks | 297 |
An overview | 317 |
Future Directions in Biomedical Research on Alcoholism | 331 |
Crystal ball or wishful thinking | 348 |
The neurochemistry of ethanol tolerance | 175 |
Structural changes in the hippocampal formation and frontal cortex after | 197 |
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acetaldehyde acetaldehyde adducts activity acute alcohol abuse alcohol dehydrogenase alcohol-fed alcoholic liver disease alcoholic patients aldehyde dehydrogenase ALDH ALDH2 amino acid animals binding Biochem Biophys blood brain Cadete-Leite calcium channels cancer carcinogenesis carcinogens cells chronic alcohol consumption chronic ethanol consumption cirrhosis Clin collagen concentrations cytosolic decreased dendritic dietary dihydropyridine effect of chronic effects of ethanol enhanced enzyme ethanol administration ethanol feeding ethanol metabolism ethanol oxidation ethanol-induced factors fatty fibrosis folate deficiency free radical function gastric Gastroenterology gene genetic glucose glutathione hepatic hepatocytes Hepatology hippocampal human liver increased induced inhibition intake intestinal isoenzymes isozymes levels Lieber lipid peroxidation mechanisms membrane mice microsomal mitochondrial mucosa myopathy NADH neurons Pharmacol phosphorylation plasma Preedy protein synthesis rat liver receptor reduced role Seitz serum skeletal muscle studies substrate subunit T.N. Palmer Tabakoff tissue toxicity tryptophan vasopressin vitamin vitro vivo withdrawal